![]() ![]() We have conducted a prospective cohort study since 2008 in Tokushima Prefecture, Japan. However, unknown factors or patterns may also affect the risk for type 2 diabetes. A number of other risk factors have also been identified for type 2 diabetes. Obesity is a key risk factor for various chronic diseases, including type 2 diabetes 2, 3. The prevalence of type 2 diabetes has been increasing globally 1. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes. ![]() Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes ( P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes ( P for trend = 0.016). ![]() On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35–69 years. ![]()
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